Research opportunities in the lab exist in the following general areas:
Microbial systems biology
- microbial systems biology: sugar signaling/metabolism and gene expression regulation
- genome scale modelling of metabolic and signalling pathways using Flux Balance analysis (FBA) and Petri Nets
- microorganisms as cell factories for industrial biotechnology
- increase of the predictability and control of biological production systems
Advanced Biochemical Techniques
- self-assembling proteins and moonlighting proteins characterization
- role of mobile genetic elements in bacteria metabolism
- investigating novel genetic circuits as potential targets for new atibacterial agents
- application of synthetic biology for microbial biotechnology
- validation of in silico models
Grants:
- SONATA BIS no. 2012/05/E/NZ2/00583 (National Science Centre) “Applying systems biology approach for analysis of the glucose signalling pathways in yeast”
- OPUS no. 2015/17/B/NZ2/01160 (National Science Centre) “Role of mobile genetic elements in bacteria metabolism. Dynamic alpha-helical polymers of Kfr- type plasmidic proteins in organization of prokaryotic mitotic spindle”.
Field of research
Biological phenomena
The functioning of living organisms depends on flawless responses to dynamic external and internal conditions. We explore the interplay between sugar signaling, sensing of metabolic flux and genes regulation as the fundamental biological phenomena.
The lab is interested in the mechanism which triggers ‘metabolic remodelling’ in cells with non optimal tRNA synthesis, the regulation of glycolysis/gluconeogenesis switch.
Metabolic Engineering
If the mechanism has been elucidated, it would answer the question, what happens in the cell at the transition between steady states.
As a consequence that would have an immense impact on the progress of pathways design, would lead to practical solutions for more predictable metabolic engineering in microorganisms, and synthetic circuits in the next generation species.
Biological systems
We believe in rational construction of biological systems based on engineering principles.
We address the fundamental questions using classic enzymes biochemistry, molecular biology, high-throughput techniques, metabolomics, proteomics, and simulating metabolism in genome-scale reconstructions of metabolic networks by Flux Balance Analysis.
The functioning of living organisms depends on flawless responses to dynamic external and internal conditions.
We explore the interplay between sugar signaling, sensing of metabolic flux and genes regulation as the fundamental biological phenomena.
The lab is interested in the mechanism which triggers ‘metabolic remodeling’, the regulation of glycolytic and gluconeogenetic activity in microorganisms.
If the mechanism has been elucidated, it would answer the question of what happens in the cell at the transition between steady states.
As a consequence, it would have an immense impact on the progress of the pathways design, which leads to practical solutions for more predictable metabolic engineering in microorganisms and construction of synthetic circuits in the next generation species.
We believe in rational construction of biological systems based on engineering principles.
We address the fundamental questions using classic enzymes biochemistry, molecular biology, biophysics, high-throughput techniques, metabolomics, proteomics and simulating metabolism in genome-scale reconstructions of metabolic networks by Flux Balance Analysis.
Join Our Research Endeavors
We invite you to collaborate with us in pioneering research that bridges biology and engineering. Explore opportunities to contribute to groundbreaking studies in metabolic engineering and synthetic biology.