Field of research

The functioning of living organisms depends on flawless responses to dynamic external and internal conditions. We explore the interplay between sugar signaling, sensing of metabolic flux and genes regulation as the fundamental biological phenomena.

The lab is interested in the  mechanism which triggers ‘metabolic remodelling’ in cells with non optimal tRNA synthesis, the  regulation of glycolysis/gluconeogenesis switch.
If the mechanism has been elucidated, it would answer the question, what happens in the cell at the transition between steady states. As a consequence that would have an immense impact on the progress of pathways design, would lead to practical solutions for more predictable metabolic engineering in microorganisms, and synthetic circuits in the next generation species.

We believe in rational construction of biological systems based on engineering principles.

We address the fundamental questions using classic enzymes biochemistry, molecular biology, high-throughput techniques, metabolomics, proteomics, and simulating metabolism in genome-scale reconstructions of metabolic networks by Flux Balance Analysis.