{"id":29,"date":"2016-06-20T14:15:42","date_gmt":"2016-06-20T14:15:42","guid":{"rendered":"http:\/\/madamczyk.ch.pw.edu.pl\/?page_id=29"},"modified":"2025-08-12T17:43:59","modified_gmt":"2025-08-12T17:43:59","slug":"research","status":"publish","type":"page","link":"https:\/\/madamczyk.ch.pw.edu.pl\/index.php\/research\/","title":{"rendered":"Research"},"content":{"rendered":"<p>[et_pb_section fb_built=&#8221;1&#8243; admin_label=&#8221;Features&#8221; _builder_version=&#8221;4.24.3&#8243; _module_preset=&#8221;default&#8221; background_color=&#8221;#006d77&#8243; custom_padding=&#8221;20px||26px|||&#8221; locked=&#8221;off&#8221; collapsed=&#8221;on&#8221; global_colors_info=&#8221;{%22#006d77%22:%91%22background_color%22%93}&#8221;][et_pb_row _builder_version=&#8221;4.23.1&#8243; _module_preset=&#8221;5138c454-be54-4233-bd3b-f8e6a8747976&#8243; custom_padding=&#8221;6px|||||&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16&#8243; _module_preset=&#8221;73121f80-a3ef-4484-8763-c3f18e3c56d2&#8243; global_colors_info=&#8221;{}&#8221;][et_pb_heading title=&#8221;Research opportunities in the lab exist in the following general areas:&#8221; _builder_version=&#8221;4.24.2&#8243; _module_preset=&#8221;c33f07d9-41e0-421a-8799-5799df695cce&#8221; title_level=&#8221;h2&#8243; title_font=&#8221;IBM Plex Sans Condensed|IBM Plex Sans Condensed_weight|||||||&#8221; title_text_color=&#8221;#FFFFFF&#8221; title_font_size=&#8221;50px&#8221; title_line_height=&#8221;1.2em&#8221; custom_margin=&#8221;||10px||false|false&#8221; title_font_size_tablet=&#8221;28px&#8221; title_font_size_phone=&#8221;20px&#8221; title_font_size_last_edited=&#8221;on|phone&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_heading][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=&#8221;1_3,1_3,1_3&#8243; make_equal=&#8221;on&#8221; _builder_version=&#8221;4.24.3&#8243; _module_preset=&#8221;5138c454-be54-4233-bd3b-f8e6a8747976&#8243; custom_padding=&#8221;0px|||||&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;4.24.3&#8243; _module_preset=&#8221;50607da8-57bc-4d4b-aaef-f02e41c2cc4a&#8221; background_color=&#8221;#FFFFFF&#8221; custom_padding=&#8221;30px|30px|30px|30px|true|true&#8221; custom_padding_tablet=&#8221;30px|30px|30px|30px|true|true&#8221; custom_padding_phone=&#8221;20px|20px|20px|20px|true|true&#8221; custom_padding_last_edited=&#8221;off|desktop&#8221; border_radii=&#8221;on|6px|6px|6px|6px&#8221; box_shadow_style=&#8221;preset1&#8243; box_shadow_vertical=&#8221;24px&#8221; box_shadow_blur=&#8221;72px&#8221; box_shadow_spread=&#8221;-12px&#8221; box_shadow_color=&#8221;rgba(0,0,0,0.12)&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_blurb title=&#8221;Microbial systems biology&#8221; use_icon=&#8221;on&#8221; font_icon=&#8221;&#xf1c0;||fa||900&#8243; icon_color=&#8221;#006d77&#8243; image_icon_width=&#8221;32px&#8221; content_max_width=&#8221;100%&#8221; _builder_version=&#8221;4.24.3&#8243; _module_preset=&#8221;212b201d-2c34-41bd-936c-851b7357d08b&#8221; header_font=&#8221;IBM Plex Sans Condensed|IBM Plex Sans Condensed_weight|||||||&#8221; header_text_color=&#8221;#0e0c19&#8243; header_font_size=&#8221;18px&#8221; header_line_height=&#8221;1.4em&#8221; body_font=&#8221;IBM Plex Sans|IBM Plex Sans_weight|||||||&#8221; body_text_color=&#8221;#3c3a47&#8243; body_font_size=&#8221;16px&#8221; body_line_height=&#8221;1.75em&#8221; body_link_text_color=&#8221;#006d77&#8243; background_mask_style=&#8221;diagonal&#8221; image_icon_custom_margin=&#8221;||||false|false&#8221; image_icon_custom_padding=&#8221;||||false|false&#8221; text_orientation=&#8221;center&#8221; animation=&#8221;off&#8221; header_font_size_tablet=&#8221;15px&#8221; header_font_size_phone=&#8221;13px&#8221; header_font_size_last_edited=&#8221;on|phone&#8221; body_font_size_tablet=&#8221;15px&#8221; body_font_size_phone=&#8221;14px&#8221; body_font_size_last_edited=&#8221;on|desktop&#8221; border_radii_image=&#8221;on|6px|6px|6px|6px&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{%22#0e0c19%22:%91%22header_text_color%22,%22header_text_color%22,%22header_text_color%22,%22header_text_color%22,%22header_text_color%22%93,%22#3c3a47%22:%91%22body_text_color%22,%22body_text_color%22,%22body_text_color%22,%22body_text_color%22,%22body_text_color%22%93,%22#006d77%22:%91%22icon_color%22%93}&#8221;]<\/p>\n<p style=\"text-align: left;\"><em><\/em><\/p>\n<ul>\n<li style=\"text-align: left;\"><em>microbial systems biology: sugar signaling\/metabolism and gene expression regulation<\/em><\/li>\n<\/ul>\n<ul>\n<li style=\"text-align: left;\"><em>genome scale modelling of metabolic and signalling pathways using Flux Balance analysis (FBA) and Petri Nets<\/em><\/li>\n<\/ul>\n<ul>\n<li style=\"text-align: left;\"><em>microorganisms as cell factories for industrial biotechnology<\/em><\/li>\n<\/ul>\n<p><em><\/em><\/p>\n<ul>\n<li style=\"text-align: left;\"><em>increase of the predictability and control of biological production systems<\/em><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p><em><\/em><\/p>\n<p>[\/et_pb_blurb][\/et_pb_column][et_pb_column type=&#8221;1_3&#8243; 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header_text_color=&#8221;#0e0c19&#8243; header_font_size=&#8221;18px&#8221; header_line_height=&#8221;1.4em&#8221; body_font=&#8221;IBM Plex Sans|IBM Plex Sans_weight|||||||&#8221; body_text_color=&#8221;#3c3a47&#8243; body_font_size=&#8221;16px&#8221; body_line_height=&#8221;1.75em&#8221; body_link_text_color=&#8221;#006d77&#8243; background_mask_style=&#8221;diagonal&#8221; image_icon_custom_margin=&#8221;||||false|false&#8221; image_icon_custom_padding=&#8221;||||false|false&#8221; text_orientation=&#8221;center&#8221; animation=&#8221;off&#8221; header_font_size_tablet=&#8221;15px&#8221; header_font_size_phone=&#8221;13px&#8221; header_font_size_last_edited=&#8221;on|phone&#8221; body_font_size_tablet=&#8221;15px&#8221; body_font_size_phone=&#8221;14px&#8221; body_font_size_last_edited=&#8221;on|desktop&#8221; border_radii_image=&#8221;on|6px|6px|6px|6px&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{%22#0e0c19%22:%91%22header_text_color%22,%22header_text_color%22,%22header_text_color%22,%22header_text_color%22,%22header_text_color%22%93,%22#3c3a47%22:%91%22body_text_color%22,%22body_text_color%22,%22body_text_color%22,%22body_text_color%22,%22body_text_color%22%93,%22#006d77%22:%91%22icon_color%22%93}&#8221;]<\/p>\n<p><em><\/em><\/p>\n<ul>\n<li style=\"text-align: left;\"><em>SONATA BIS no. 2012\/05\/E\/NZ2\/00583 (National Science Centre) \u201cApplying systems biology approach for analysis of the glucose signalling pathways in yeast\u201d <\/em><em><\/em><\/li>\n<\/ul>\n<p style=\"text-align: left;\"><em><\/em><\/p>\n<ul>\n<li style=\"text-align: left;\"><em>OPUS no. 2015\/17\/B\/NZ2\/01160 (National Science Centre) \u201cRole of mobile genetic elements in bacteria metabolism. Dynamic alpha-helical polymers of Kfr- type plasmidic proteins in organization of prokaryotic mitotic spindle\u201d.<\/em><\/li>\n<\/ul>\n<p>[\/et_pb_blurb][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; admin_label=&#8221;Services&#8221; _builder_version=&#8221;4.18.0&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;-1px|||||&#8221; custom_padding=&#8221;0px||2px|||&#8221; locked=&#8221;off&#8221; collapsed=&#8221;on&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_row _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;5138c454-be54-4233-bd3b-f8e6a8747976&#8243; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.16.0&#8243; _module_preset=&#8221;73121f80-a3ef-4484-8763-c3f18e3c56d2&#8243; global_colors_info=&#8221;{}&#8221;][et_pb_heading title=&#8221;Field of research&#8221; _builder_version=&#8221;4.25.1&#8243; _module_preset=&#8221;c33f07d9-41e0-421a-8799-5799df695cce&#8221; title_level=&#8221;h2&#8243; title_font=&#8221;IBM Plex Sans Condensed|IBM Plex Sans Condensed_weight|||||||&#8221; title_text_align=&#8221;center&#8221; title_text_color=&#8221;#0e0c19&#8243; title_font_size=&#8221;50px&#8221; title_line_height=&#8221;1.2em&#8221; custom_margin=&#8221;||10px||false|false&#8221; title_font_size_tablet=&#8221;28px&#8221; title_font_size_phone=&#8221;20px&#8221; title_font_size_last_edited=&#8221;on|phone&#8221; global_colors_info=&#8221;{}&#8221;][\/et_pb_heading][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=&#8221;1_3,1_3,1_3&#8243; make_equal=&#8221;on&#8221; _builder_version=&#8221;4.25.2&#8243; _module_preset=&#8221;5138c454-be54-4233-bd3b-f8e6a8747976&#8243; custom_padding=&#8221;8px|||||&#8221; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;4.25.2&#8243; _module_preset=&#8221;deb82190-c402-496d-9cea-a1d08a63686c&#8221; use_background_color_gradient=&#8221;on&#8221; background_color_gradient_stops=&#8221;rgba(255,255,255,0.85) 0%|#f9f9f9 87%&#8221; 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image_icon_custom_padding=&#8221;||||false|false&#8221; custom_margin=&#8221;-100px|||||&#8221; custom_padding=&#8221;0px|||||&#8221; animation=&#8221;off&#8221; header_font_size_tablet=&#8221;15px&#8221; header_font_size_phone=&#8221;13px&#8221; header_font_size_last_edited=&#8221;on|phone&#8221; body_font_size_tablet=&#8221;15px&#8221; body_font_size_phone=&#8221;14px&#8221; body_font_size_last_edited=&#8221;on|desktop&#8221; border_radii_image=&#8221;on|6px|6px|6px|6px&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{%22#0e0c19%22:%91%22header_text_color%22,%22header_text_color%22,%22header_text_color%22,%22header_text_color%22,%22header_text_color%22%93,%22#3c3a47%22:%91%22body_text_color%22,%22body_text_color%22,%22body_text_color%22,%22body_text_color%22,%22body_text_color%22%93,%22#006d77%22:%91%22icon_color%22%93}&#8221;]<\/p>\n<p style=\"text-align: center;\">The functioning of living organisms depends on flawless responses to dynamic external and internal conditions. We explore the interplay between sugar signaling, sensing of metabolic flux and genes regulation as the fundamental biological phenomena.<\/p>\n<p style=\"text-align: center;\">The lab is interested in the mechanism which triggers \u2018metabolic remodelling\u2019 in cells with non optimal tRNA synthesis, the regulation of glycolysis\/gluconeogenesis switch.<\/p>\n<p>[\/et_pb_blurb][\/et_pb_column][et_pb_column type=&#8221;1_3&#8243; _builder_version=&#8221;4.25.2&#8243; _module_preset=&#8221;deb82190-c402-496d-9cea-a1d08a63686c&#8221; use_background_color_gradient=&#8221;on&#8221; background_color_gradient_stops=&#8221;rgba(255,255,255,0.85) 0%|#f9f9f9 87%&#8221; background_color_gradient_overlays_image=&#8221;on&#8221; background_image=&#8221;https:\/\/images.unsplash.com\/photo-1582719202047-76d3432ee323?ixid=M3w1ODkyNzF8MHwxfHNlYXJjaHwxfHxnZW5ldGljJTIwcmVzZWFyY2h8ZW58MHwxfHx8MTc0NDQ3ODg1MXww&#038;ixlib=rb-4.0.3&#038;fm=webp&#038;fit=crop&#038;crop=entropy&#038;w=800&#038;h=1066&#038;q=20&#038;dpr=2&#8243; 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icon_color=&#8221;#006d77&#8243; image_icon_width=&#8221;32px&#8221; icon_alignment=&#8221;left&#8221; content_max_width=&#8221;100%&#8221; _builder_version=&#8221;4.24.3&#8243; _module_preset=&#8221;212b201d-2c34-41bd-936c-851b7357d08b&#8221; header_font=&#8221;IBM Plex Sans Condensed|IBM Plex Sans Condensed_weight|||||||&#8221; header_text_color=&#8221;#0e0c19&#8243; header_font_size=&#8221;18px&#8221; header_line_height=&#8221;1.4em&#8221; body_font=&#8221;IBM Plex Sans|IBM Plex Sans_weight|||||||&#8221; body_text_color=&#8221;#3c3a47&#8243; body_font_size=&#8221;16px&#8221; body_line_height=&#8221;1.75em&#8221; body_link_text_color=&#8221;#006d77&#8243; background_mask_style=&#8221;diagonal&#8221; image_icon_custom_margin=&#8221;||||false|false&#8221; image_icon_custom_padding=&#8221;||||false|false&#8221; custom_margin=&#8221;-100px|||||&#8221; animation=&#8221;off&#8221; header_font_size_tablet=&#8221;15px&#8221; header_font_size_phone=&#8221;13px&#8221; header_font_size_last_edited=&#8221;on|phone&#8221; body_font_size_tablet=&#8221;15px&#8221; body_font_size_phone=&#8221;14px&#8221; body_font_size_last_edited=&#8221;on|desktop&#8221; border_radii_image=&#8221;on|6px|6px|6px|6px&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{%22#0e0c19%22:%91%22header_text_color%22,%22header_text_color%22,%22header_text_color%22,%22header_text_color%22,%22header_text_color%22%93,%22#3c3a47%22:%91%22body_text_color%22,%22body_text_color%22,%22body_text_color%22,%22body_text_color%22,%22body_text_color%22%93,%22#006d77%22:%91%22icon_color%22%93}&#8221;]<\/p>\n<p>If the mechanism has been elucidated, it would answer the question, what happens in the cell at the transition between steady states.<\/p>\n<p>As a consequence that would have an immense impact on the progress of pathways design, would lead to practical solutions for more predictable metabolic engineering in microorganisms, and synthetic circuits in the next generation species.<\/p>\n<p>[\/et_pb_blurb][\/et_pb_column][et_pb_column type=&#8221;1_3&#8243; 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body_font=&#8221;IBM Plex Sans|IBM Plex Sans_weight|||||||&#8221; body_text_color=&#8221;#3c3a47&#8243; body_font_size=&#8221;16px&#8221; body_line_height=&#8221;1.75em&#8221; body_link_text_color=&#8221;#006d77&#8243; background_mask_style=&#8221;diagonal&#8221; image_icon_custom_margin=&#8221;||||false|false&#8221; image_icon_custom_padding=&#8221;||||false|false&#8221; custom_margin=&#8221;-100px|||||&#8221; animation=&#8221;off&#8221; header_font_size_tablet=&#8221;15px&#8221; header_font_size_phone=&#8221;13px&#8221; header_font_size_last_edited=&#8221;on|phone&#8221; body_font_size_tablet=&#8221;15px&#8221; body_font_size_phone=&#8221;14px&#8221; body_font_size_last_edited=&#8221;on|desktop&#8221; border_radii_image=&#8221;on|6px|6px|6px|6px&#8221; locked=&#8221;off&#8221; global_colors_info=&#8221;{%22#0e0c19%22:%91%22header_text_color%22,%22header_text_color%22,%22header_text_color%22,%22header_text_color%22,%22header_text_color%22%93,%22#3c3a47%22:%91%22body_text_color%22,%22body_text_color%22,%22body_text_color%22,%22body_text_color%22,%22body_text_color%22%93,%22#006d77%22:%91%22icon_color%22%93}&#8221;]<\/p>\n<p>We believe in rational construction of biological systems based on engineering principles.<\/p>\n<p>We address the fundamental questions using classic enzymes biochemistry, molecular biology, high-throughput techniques, metabolomics, proteomics, and simulating metabolism in genome-scale reconstructions of metabolic networks by Flux Balance Analysis.<\/p>\n<p>[\/et_pb_blurb][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=&#8221;1&#8243; 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body_font=&#8221;IBM Plex Sans|IBM Plex Sans_weight|||||||&#8221; body_text_color=&#8221;#FFFFFF&#8221; body_font_size=&#8221;16px&#8221; body_line_height=&#8221;1.75em&#8221; body_link_font=&#8221;||||on||||&#8221; body_link_text_color=&#8221;#FFFFFF&#8221; background_mask_style=&#8221;diagonal&#8221; custom_padding=&#8221;|||0px||&#8221; animation=&#8221;off&#8221; header_font_size_tablet=&#8221;15px&#8221; header_font_size_phone=&#8221;14px&#8221; header_font_size_last_edited=&#8221;on|phone&#8221; body_font_size_tablet=&#8221;15px&#8221; body_font_size_phone=&#8221;14px&#8221; body_font_size_last_edited=&#8221;on|desktop&#8221; border_radii_image=&#8221;on|6px|6px|6px|6px&#8221; global_colors_info=&#8221;{%22gcid-f2943306-fa6c-45f0-b632-5fc00151366a%22:%91%22button_text_color%22%93,%22gcid-36fd78a7-34bc-404d-873c-dafa34efaae5%22:%91%22button_text_color%22%93}&#8221;]<\/p>\n<p>The functioning of living organisms depends on flawless responses to dynamic external and internal conditions.<\/p>\n<p>We explore the interplay between sugar signaling, sensing of metabolic flux and genes regulation as the fundamental biological phenomena.<\/p>\n<p>The lab is interested in the mechanism which triggers \u2018metabolic remodeling\u2019, the regulation of glycolytic and gluconeogenetic activity in microorganisms.<\/p>\n<p>If the mechanism has been elucidated, it would answer the question of what happens in the cell at the transition between steady states.<\/p>\n<p>[\/et_pb_blurb][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=&#8221;3_5,2_5&#8243; 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body_line_height=&#8221;1.75em&#8221; body_link_font=&#8221;||||on||||&#8221; body_link_text_color=&#8221;#FFFFFF&#8221; background_mask_style=&#8221;diagonal&#8221; custom_margin=&#8221;|-316px||||&#8221; custom_padding=&#8221;|240px||||&#8221; animation=&#8221;off&#8221; header_font_size_tablet=&#8221;15px&#8221; header_font_size_phone=&#8221;14px&#8221; header_font_size_last_edited=&#8221;on|phone&#8221; body_font_size_tablet=&#8221;15px&#8221; body_font_size_phone=&#8221;14px&#8221; body_font_size_last_edited=&#8221;on|desktop&#8221; border_radii_image=&#8221;on|6px|6px|6px|6px&#8221; global_colors_info=&#8221;{%22gcid-f2943306-fa6c-45f0-b632-5fc00151366a%22:%91%22button_text_color%22%93,%22gcid-36fd78a7-34bc-404d-873c-dafa34efaae5%22:%91%22button_text_color%22%93}&#8221;]<\/p>\n<p>&nbsp;<\/p>\n<p>As a consequence, it would have an immense impact on the progress of the pathways design, which leads to practical solutions for more predictable metabolic engineering in microorganisms and construction of synthetic circuits in the next generation species.<\/p>\n<p>We believe in rational construction of biological systems based on engineering principles.<\/p>\n<p>&nbsp;<\/p>\n<p>[\/et_pb_blurb][\/et_pb_column][et_pb_column type=&#8221;2_5&#8243; 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header_font_size_last_edited=&#8221;on|phone&#8221; body_font_size_tablet=&#8221;15px&#8221; body_font_size_phone=&#8221;14px&#8221; body_font_size_last_edited=&#8221;on|desktop&#8221; border_radii_image=&#8221;on|6px|6px|6px|6px&#8221; global_colors_info=&#8221;{%22gcid-f2943306-fa6c-45f0-b632-5fc00151366a%22:%91%22button_text_color%22%93,%22gcid-36fd78a7-34bc-404d-873c-dafa34efaae5%22:%91%22button_text_color%22%93}&#8221;]<\/p>\n<p>We address the fundamental questions using classic enzymes biochemistry, molecular biology, biophysics, high-throughput techniques, metabolomics, proteomics and simulating metabolism in genome-scale reconstructions of metabolic networks by Flux Balance Analysis.<\/p>\n<p>&nbsp;<\/p>\n<p>[\/et_pb_blurb][et_pb_blurb title=&#8221;Join Our Research Endeavors&#8221; url=&#8221;https:\/\/madamczyk.ch.pw.edu.pl\/index.php\/contact\/&#8221; use_icon=&#8221;on&#8221; font_icon=&#8221;&#xf1d8;||fa||400&#8243; icon_color=&#8221;#FFFFFF&#8221; icon_placement=&#8221;left&#8221; image_icon_width=&#8221;40px&#8221; content_max_width=&#8221;100%&#8221; _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;ca79a742-981f-479f-a8a2-3a0292efaff0&#8243; header_font=&#8221;IBM Plex Sans Condensed|IBM Plex Sans Condensed_weight|||||||&#8221; header_text_color=&#8221;#FFFFFF&#8221; header_font_size=&#8221;18px&#8221; header_line_height=&#8221;1.4em&#8221; body_font=&#8221;IBM Plex Sans|IBM Plex Sans_weight|||||||&#8221; body_text_color=&#8221;#FFFFFF&#8221; body_font_size=&#8221;16px&#8221; body_line_height=&#8221;1.75em&#8221; body_link_font=&#8221;||||on||||&#8221; body_link_text_color=&#8221;#FFFFFF&#8221; background_mask_style=&#8221;diagonal&#8221; animation=&#8221;off&#8221; header_font_size_tablet=&#8221;15px&#8221; header_font_size_phone=&#8221;14px&#8221; header_font_size_last_edited=&#8221;on|phone&#8221; body_font_size_tablet=&#8221;15px&#8221; body_font_size_phone=&#8221;14px&#8221; body_font_size_last_edited=&#8221;on|desktop&#8221; border_radii_image=&#8221;on|6px|6px|6px|6px&#8221; global_colors_info=&#8221;{%22gcid-f2943306-fa6c-45f0-b632-5fc00151366a%22:%91%22button_text_color%22%93,%22gcid-36fd78a7-34bc-404d-873c-dafa34efaae5%22:%91%22button_text_color%22%93}&#8221;]<\/p>\n<p>We invite you to collaborate with us in pioneering research that bridges biology and engineering. Explore opportunities to contribute to groundbreaking studies in metabolic engineering and synthetic biology.<\/p>\n<p>[\/et_pb_blurb][et_pb_text _builder_version=&#8221;4.27.4&#8243; _module_preset=&#8221;default&#8221; custom_margin=&#8221;-7px|||||&#8221; custom_padding=&#8221;5px|||||&#8221; inline_fonts=&#8221;Abel&#8221; global_colors_info=&#8221;{}&#8221;]<\/p>\n<h3><span style=\"color: #000000;\"><strong>We Collaborate with researchers at:<\/strong><\/span><\/h3>\n<ul>\n<li><strong><span style=\"color: #ffffff;\"><span style=\"font-family: inherit;\">The University of Warwick, UK<\/span><\/span><\/strong><\/li>\n<li><strong><span style=\"color: #ffffff;\"><span style=\"font-family: inherit;\">The University of Birmingham, UK<\/span><\/span><\/strong><\/li>\n<li><strong><span style=\"color: #ffffff;\"><span style=\"font-family: inherit;\">The University of Manchester, UK<\/span><\/span><\/strong><\/li>\n<li><strong><span style=\"color: #ffffff;\"><span style=\"font-family: inherit;\">Certara, UK<\/span><\/span><\/strong><\/li>\n<li><strong><span style=\"color: #ffffff;\"><span style=\"font-family: inherit;\">Faculty of Mathematics, Informatics and Mechanics of University of Warsaw, Poland<\/span><\/span><\/strong><\/li>\n<li><strong><span style=\"color: #ffffff;\"><span style=\"font-family: inherit;\">Institute of Biochemistry and Biophysics, Polish Academy of Sciences (IBB PAS)<\/span><\/span><\/strong><\/li>\n<li><strong><span style=\"color: #ffffff;\"><span style=\"font-family: inherit;\">Institute of Physical Chemistry Polish Academy of Sciences \u00a0(IChF PAS) Poland<\/span><\/span><\/strong><\/li>\n<li><strong><span style=\"color: #ffffff;\"><span style=\"font-family: inherit;\">Faculty of Farmacy, Collegium Medicum in Bydgoszczy, Poland<\/span><\/span><\/strong><\/li>\n<li><strong><span style=\"color: #ffffff;\"><span style=\"font-family: inherit;\">Faculty of Chemistry\u00a0Lodz University of Technology, Poland<\/span><\/span><\/strong><\/li>\n<li><strong><span style=\"color: #ffffff;\"><span style=\"font-family: inherit;\">Faculty of Electronics and Information Technology at Warsaw University of Technology (WUT), Poland<\/span><\/span><\/strong><\/li>\n<\/ul>\n<p>[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=&#8221;4.24.2&#8243; _module_preset=&#8221;5138c454-be54-4233-bd3b-f8e6a8747976&#8243; global_colors_info=&#8221;{}&#8221;][et_pb_column type=&#8221;4_4&#8243; _builder_version=&#8221;4.18.0&#8243; _module_preset=&#8221;73121f80-a3ef-4484-8763-c3f18e3c56d2&#8243; global_colors_info=&#8221;{}&#8221;][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>microbial systems biology: sugar signaling\/metabolism and gene expression regulation genome scale modelling of metabolic and signalling pathways using Flux Balance analysis (FBA) and Petri Nets microorganisms as cell factories for industrial biotechnology increase of the predictability and control of biological production systems &nbsp; self-assembling proteins and moonlighting proteins characterization role of mobile genetic elements in [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"<strong>Research opportunities in the lab exist in the following general areas<\/strong>\n<ul style=\"list-style-type: square;\">\n \t<li>microbial systems biology: sugar signaling\/metabolism and gene expression regulation<\/li>\n \t<li>genome scale modelling of metabolic and signalling pathways using Flux Balance analysis (FBA) and Petri Nets<\/li>\n \t<li>microorganisms as cell factories for industrial biotechnology<\/li>\n \t<li>increase of the predictability and control of biological production systems<\/li>\n \t<li>self-assembling proteins and moonlighting proteins characterization<\/li>\n \t<li>role of mobile genetic elements in bacteria metabolism<\/li>\n \t<li>investigating novel genetic circuits as potential targets for new atibacterial agents<\/li>\n \t<li>application of synthetic biology for microbial biotechnology<\/li>\n \t<li>\u00a0validation of <em>in silico<\/em> models<\/li>\n<\/ul>\n<img class=\"alignnone wp-image-83\" src=\"http:\/\/madamczyk.ch.pw.edu.pl\/wp-content\/uploads\/2016\/06\/drozdze-300x145.png\" alt=\"drozdze\" width=\"418\" height=\"202\" \/>\n\n<strong>Grants<\/strong>\n<ul style=\"list-style-type: square;\">\n \t<li>SONATA BIS no. 2012\/05\/E\/NZ2\/00583 (National Science Centre) \"Applying systems biology approach for analysis of the glucose signalling pathways in yeast\"<\/li>\n \t<li>OPUS no. 2015\/17\/B\/NZ2\/01160 (National Science Centre) \"<span style=\"font-size: medium;\">Role of mobile genetic elements in bacteria metabolism. Dynamic alpha-helical polymers of Kfr- type plasmidic proteins in organization of prokaryotic mitotic spindle\u201d<\/span><span style=\"font-size: medium;\">.<\/span><\/li>\n \t<li><\/li>\n \t<li><a href=\"http:\/\/madamczyk.ch.pw.edu.pl\/wp-content\/uploads\/2016\/06\/NCN.bmp\"><img class=\"alignnone size-full wp-image-93\" src=\"http:\/\/madamczyk.ch.pw.edu.pl\/wp-content\/uploads\/2016\/06\/NCN.bmp\" alt=\"NCN\" width=\"450\" height=\"77\" \/><\/a><\/li>\n<\/ul>\n<strong>\u00a0<\/strong>\n\n<strong>\u00a0<\/strong>","_et_gb_content_width":"","footnotes":""},"class_list":["post-29","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/madamczyk.ch.pw.edu.pl\/index.php\/wp-json\/wp\/v2\/pages\/29","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/madamczyk.ch.pw.edu.pl\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/madamczyk.ch.pw.edu.pl\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/madamczyk.ch.pw.edu.pl\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/madamczyk.ch.pw.edu.pl\/index.php\/wp-json\/wp\/v2\/comments?post=29"}],"version-history":[{"count":31,"href":"https:\/\/madamczyk.ch.pw.edu.pl\/index.php\/wp-json\/wp\/v2\/pages\/29\/revisions"}],"predecessor-version":[{"id":674,"href":"https:\/\/madamczyk.ch.pw.edu.pl\/index.php\/wp-json\/wp\/v2\/pages\/29\/revisions\/674"}],"wp:attachment":[{"href":"https:\/\/madamczyk.ch.pw.edu.pl\/index.php\/wp-json\/wp\/v2\/media?parent=29"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}